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1 day ago
| Closing on Apr 16
Abstract
The mechanisms that drive the migration and guidance of cell assemblies during embryonic development or cancer metastasis are diverse and remain poorly understood. Based on a perturbative approach, our project aims at investigating the dynamical migratory response of...
1 day ago
| Closing on Apr 16
Abstract
We apply approaches from the field of artificial intelligence (Answer Set Programming) to represent gene networks, model gene regulatory circuits, and study their dynamics. We explore the reachability of states and attractors, calculating their forces and robustness,...
1 day ago
| Closing on Apr 16
Abstract
Double membrane vesicles (DMVs) form in the host cell upon infection by SARS CoV-2. DMVs allow viral replication to proceed unnoticed by the immune system of the host cell, as immunogenic factors such as the viral double stranded RNA, an intermediate replication...
1 day ago
| Closing on Apr 16
Abstract
Self-localization is essential to animal survival. In rodents, this ability relies on functional interactions between interconnected structures in the temporal lobe. Communication between these structures is facilitated by oscillations of neuronal activity notably in...
2 days ago
| Closing on Apr 16
Abstract
Dinitrogen (N2) fixing microbes (diazotrophs) provide the main source of nitrogen in the ocean, sustaining ecosystem productivity. Thus, quantifying their abundance, diversity and spatiotemporal distribution is of utmost relevance. Current methods to quantify and...
2 days ago
| Closing on Apr 16
Abstract
Mitochondrial oxidative phosphorylation (OXPHOS) is an essential source of ATP for a cell’s energy needs and is a highly dynamic and controlled process during cell differentiation and animal development and its dysfunction drives plethora human diseases and cancer....
2 days ago
| Closing on Apr 16
Abstract
In cancer there is a link between metabolic and epigenetic changes but the mechanisms involved are unknown due to technical limitations. There are no methods to study concomitantly metabolism and epigenetics in tumour-derived cells of patients. Monocyte derived...
2 days ago
| Closing on Apr 16
Abstract
Our project is on in-silico drug discovery: based on drug chemical synthesis, and thanks to the unprecedented molecular-level information enabled by ultrafast atomic force microscopy, we will use state-of-the-art mathematical algorithms to analyse visual data and set...
2 days ago
| Closing on Apr 16
Abstract
Mitochondria are essential organelles, which produce cellular energy in the form of ATP are involved in many other cellular processes (1) and functionally adapt to cellular needs. In this project, we will combine deep learning with mitochondrial computational biology...
2 days ago
| Closing on Apr 16
Abstract
Behavioral studies have shown that mice can form social memories, i.e., to remember familiar conspecifics. Recent optogenetic studies have demonstrated that assemblies of excitatory neurons in hippocampal ventral CA1 constitute a primary site of social memory....
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