We offer a full-time position at the ULB Center for Diabetes Research in Brussels.
The Molecular Mechanisms of Polygenic and Monogenic Diabetes’s research Group led by Dr. Mariana Igoillo-Esteve is seeking highly a motivated post-doctoral researcher to study the pathophysiological mechanisms of diabetes associated with tRNA epitranscriptome dysregulations caused by TRMT10A deficiency. The successful applicant will join the ULB Center for Diabetes Research, characterised by a remarkable track record in research excellence.
The position is intended to elucidate the molecular mechanisms of TRMT10A-deficiency-mediated diabetes (1-3). The project involves in vitro and in vivo models of TRMT10A deficiency including RNAi-mediated gene silencing in human β-cells, iPSC-derived β-cells from TRMT10A-deficient patients and control individuals, CRISPR/Cas-9-mediated TRMT10A knockout iPSC-derived β-cells (to be used in small RNA sequencing and proteomic experiments), and TRMT10A knockout mice to study the molecular mechanisms underlying pancreatic β-cell demise caused by altered tRNA modification and fragmentation.
The ULB Center for Diabetes Research https://www.ulbcdiabres.com/offers an excellent environment for innovative science.
We believe in a strong scientific commitment and reproducible findings to contribute to translate fundamental science to the clinic by collaborative efforts between scientists, physicians and the industry.
Please send your letter of intent, curriculum vitae (including publication list), and the name of 2-3 reference persons (with email address and telephone number) to firstname.lastname@example.org
Mariana Igoillo Esteve, PhD
Head, Molecular Mechanisms of Polygenic and Monogenic Diabetes’s research Group
ULB Center for Diabetes Research
Universite libre de Bruxelles (ULB)
808 Route de Lennik
Tel: +32 2 555 6138
Fax: +32 2 555 6239
Salary: Approximately 2300 € after tax.
Duration: 1 year full time in the first instance (with possibility of 2 extra years renewal if the candidate shows adequacy for the position)
Starting date: October 1st 2020
Deadline for the submission of applications: Positions open until filled
Publications by the PI related with the project
1. Igoillo-Esteve, M., Genin, A., Lambert, N., Desir, J., Pirson, I., Abdulkarim, B., Simonis, N., Drielsma, A., Marselli, L., Marchetti, P. et al. (2013) tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. PLoS Genet, 9, e1003888.
2. Cosentino, C., Toivonen, S., Diaz Villamil, E., Atta, M., Ravanat, J.L., Demine, S., Schiavo, A.A., Pachera, N., Deglasse, J.P., Jonas, J.C. et al. (2018) Pancreatic beta-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res, 46, 10302-10318.
3. Cosentino, C., Cnop, M. and Igoillo-Esteve, M. (2019) The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic beta-cell failure. Endocrinology.Continue reading
|Employer||Université libre de Bruxelles (ULB)|
|Job location||Avenue Franklin Roosevelt 50, 1050 Brussels|
|Published||July 13, 2020|
|Job types||Postdoc  |
|Fields||Physiology,   Molecular Biology,   Cell Biology,   Endocrinology  |