Research Areas: Immune Deficiency and Cancer Predisposition
Working hours: Full-time
To strengthen our excellent research team, which is focused on the development and research of innovative approaches for the treatment of childhood cancer, we are looking for a postdoctoral researcher (m/f/d). In this responsible role, you will have the unique opportunity to be part of a multidisciplinary competence center for pediatric oncology, and to have a direct influence on the development of new cancer therapies.
Kaan Boztug, a leading expert in research on immune deficiencies and bone marrow failure syndromes and PI of an ERC Consolidator grant (“iDysChart”), acts as Scientific Director of the St. Anna Children’s Cancer Research Institute (https://science.ccri.at/research/research-areas/immunology/immune-deficiency-cancer-predisposition-precision-oncology/). The group works at the interface of inborn immune disorders and inherited predisposition to childhood tumors, aiming to understand fundamental mechanisms of immune surveillance relevant to pediatric oncology and immunotherapy approaches. In close collaboration with several other groups at the institute and the St. Anna Children’s Hospital next door, they aim to translate the molecular understanding of childhood cancer (predisposition) to specific pathway modulations for the identification of targeted treatment approaches for pediatric cancer patients.
The successful candidate would join one of the following projects:
Project 1: Deciphering the molecular basis of autoimmunity and autoinflammation
The central challenge for the human immune system is the efficient recognition of and protection against foreign antigen. Disorders in the protection system can lead to autoimmunity and/or autoinflammation, as observed in many diseases. Previous studies of inborn immune defects have enabled discovery of novel disease entities and key biological mechanisms of immune homeostasis (e.g. Salzer et al Nat Immunol 2016; Ozen et al NEJM 2017; Somekh et al Blood 2019; Serwas et al Nat Commun 2019; Ghosh et al Blood 2020; Salzer et al Science Immunol 2020).
The project will investigate the key mechanisms of new monogenic defects causing immunodeficiency with predominant autoimmunity/autoinflammation, including network approaches, detailed dissection of disease mechanisms, and chemical and genetic screens to complement human disease gene discovery and investigating potential routes for therapeutic modulation.
Project 2: Identifying and understanding inherited bone marrow failure syndromes including ribosomopathies
Ribosomopathies are a group of rare diseases characterized by an impaired synthesis or function of ribosomes, caused by inherited genetic mutations. These diseases result in a failure of the bone marrow to properly produce blood cells. As part of a European consortium (RiboEurope), and building on prior experience with other bone marrow failure syndromes including congenital neutropenia (Boztug et al NEJM 2009; Boztug et al Nat Genet 2014), the group of Kaan Boztug studies known and novel genetic defects causing Diamond-Blackfan anemia (DBA) and related disorders, which are characterized by an elevated risk of progression to malignant disease (e.g. acute myeloid leukemia, AML).
As a Postdoc, you will
Who we are
The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable city and one of Europe’s most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology (IMBA) and the Institute of Molecular Pathology (IMP).
The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or expression, or any other characteristic protected by applicable laws, regulations and ordinances.
Please send your application via email to Kaan Boztug, email@example.com. Applications should at least contain your Curriculum Vitae, a cover letter, list of publications (please mark / explain your three top contributions), and the contact details of three references. The deadline for the application is 20th of September 2020. Applications will be reviewed on a rolling basis until the position is filled.
|Title||Postdoctoral Fellow (m/f/d) in Immunology, Genetics, Precision Medicine|
|Employer||St. Anna Children's Cancer Research Institute (CCRI)|
|Job location||Zimmermannplatz 10, 1090 Vienna|
|Published||September 23, 2020|
|Job types||Postdoc  |
|Fields||Immunology,   Genetics,   Internal Medicine (General Medicine)  |