At the Lab for Complex Genetics we are interested in finding genetic and transcriptomic markers that influence complex disease development and disease subtypes. We use a translational genetics approach that starts from clinical questions, and investigate these using biological samples from patients and from healthy controls. One of our focus areas is Alzheimer’s disease (AD), for which we collaborate closely with the memory clinic UZ Leuven and the Lab for Cognitive Neurology, headed by Prof Rik Vandenberghe. More information can be found on our website.
You will play a key role in the collaborative ‘PRISMA’ project (Polygenic Risk scoring and deep-Immunophenotyping Strategy to Master Alzheimer’s disease). Complex diseases like AD have unknown causes, and are usually diagnosed when already in a more advanced stage. Knowledge of the very early stages of disease is crucial to be able to develop new therapies, and to find biomarkers that help in identifying individuals at risk and stratifying patients as early as possible.
You will structure, curate and analyze large datasets integrating biological (genetic, transcriptomic,…) and clinical (disease course, brain imaging, …) data of unique prospective cohorts of cognitively intact healthy older adults, as well as a memory-clinic based AD research cohort. In particular, you will calculate whole genome and pathway-specific polygenic risk scores (PRS) for all study participants; and assess the correlation between PRS and disease stages/manifestations in AD.
You will manage this project, and report and communicate on progress in meetings and video conferences. You will be co-responsible for successful completion of this project, and for the delivery of project outcomes. You will provide technical advice and guidance to less experienced team members where applicable (eg co-supervise Master thesis and PhD students).
Essential knowledge, skills, and experience required:
Additional desirable skills and experience:
For more information please contact Prof. dr. Isabelle Cleynen, mail: firstname.lastname@example.org.
You can apply for this job no later than August 09, 2020 via the online application tool
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|Title||Postdoctoral Scientist or PhD Trainee in Bioinformatics: Polygenic Risk Scores|
|Job location||Oude Markt 13, 3000 Leuven|
|Published||July 8, 2020|
|Application deadline||August 9, 2020|
|Job types||Postdoc,   PhD  |
|Fields||Biomedical Engineering,   Bioinformatics,   Genetics,   Bioengineering,   Computational Biology  |