The laboratory of professor Geert Carmeliet is focusing on cell metabolism of skeletal cells in bone physiology and disease and on tumor cell metabolism in bone metastasis. The lab is looking for a dynamic, highly motivated postdoctoral researcher to join the team. Our recent work shows that metabolism of skeletal cells regulates bone development and is crucial for bone regeneration (Stegen S, Cell Metab 2016; Stegen S, Nature 2019; van Gastel N, Nature 2020; Stegen S, Dev Cell 2020). Moreover, these studies reveal that targeting skeletal cell metabolism could be a possible therapeutic strategy to improve bone regeneration and to treat skeletal disorders such as osteoporosis and osteoarthritis. In addition, tumor cell metabolism seems to contribute to bone metastasis. The current aim of the lab is to characterize in-depth (i) the metabolic regulation of different skeletal cell types and (ii) the metabolic adaptations in bone-metastatic tumor cells. We will combine advanced metabolic and transcriptomic analyses with state-of-the-art cell biological and molecular assays. The importance of the identified metabolic pathways will be validated by genetic or pharmacological approaches in vitro and in preclinical bone pathology models in mice.
For more information please contact Prof. Geert Carmeliet, mail: firstname.lastname@example.org
Your application file should contain complete CV, motivation letter, list of publications, summary of past research and contact information or reference letter of 2 or 3 referees.
The KU Leuven is very international, close to Brussels, at the heart of Europe
For more information please contact Prof. dr. Geert Carmeliet, tel.: +32 16 33 07 31, mail: email@example.com.
You can apply for this job no later than July 31, 2020 via the online application tool
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|Title||Cell Metabolism in Skeletal Development and Disorders|
|Job location||Oude Markt 13, 3000 Leuven|
|Published||June 3, 2020|
|Application deadline||July 31, 2020|
|Job types||Postdoc  |
|Fields||Biomedical Engineering,   Biomedicine,   Biochemistry,   Pathology,   Molecular Biology,   Cell Biology,   Bioengineering,   Regenerative Medicine  |