Last modification : Wednesday, August 14, 2019
For a joint project between the Antibiotics & Resistance Unit of Sciensano and the KU Leuven Department of Microbial and Molecular Systems, we are looking for a highly talented and motivated pre-doctoral student interested in antibiotic resistance development in Salmonella.
Salmonella enterica serovar Kentucky (S. Kentucky) is a common cause of gastro-enteritis. Although resistance to critically-important antibiotics for human medicine is rare among Salmonella species, the clonal variant S. Kentucky ST198 poses an exemption. Phylogeographic analysis indicates this clone first emerged in Egypt around 1989, before disseminating into Northern, Southern and Western Africa, and then further to the Middle East, Asia and Europe. It is extremely resistant to commonly used antibiotics, and poses a real threat to human health. Although it is meticulously monitored, the underlying mechanisms explaining its evolutionary success so far remain cryptic. In this project, you will perform a detailed investigation of the genetic background and specific features of this clone, in a broader context of elucidating why certain pathogens are more prone to incorporate antimicrobial resistance traits.
This project is financed by a branch of Horizon 2020 which specifically focuses on ‘One Health’ research. It is a collaboration between Sciensano and two expert groups in Salmonella genetics and cell biology, the Laboratory of Food Microbiology at KU Leuven (BE) and the Institut National de la Recherche Agronomique (INRA, FR).
You will be associated with the National Reference Laboratory of Salmonella (Sciensano) and the Lab of Food Microbiology (KU Leuven), with regular research visits to INRA (Tours, FR). The project starts close to the clinical reality of drug resistance, and implements state-of-the-art DNA sequencing technology (Illumina/NanoPore) to map the genetic background of this successful clone. Then, you will study interactions between various genetic elements using advanced molecular techniques and live cell biology to unravel the genetic factors contributing to the success of S. Kentucky ST198.
You are supervised by experienced scientists in genetics, cell biology and microbiology.
You will present the results of your study at national and international meetings and conferences, where you will interact with (inter)national experts, and condense these results in peer-reviewed publications and a PhD dissertation.
In addition to your CV and letter of application, please also add an overview of your study results and the names of three references who may be contacted.
For more information please contact Dr. Pieter-Jan Ceyssens (email@example.com) or Prof. Abram Aertsen (firstname.lastname@example.org).
You can apply for this job no later than September 15, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.Continue reading
|Title||Molecular Elucidation of the Evolutionary Succes of Salmonella Kentucky ST198|
|Job location||Oude Markt 13, 3000 Leuven|
|Published||August 16, 2019|
|Application deadline||September 15, 2019|
|Job types||Research assistant  |
|Fields||Biomedicine,   Microbiology,   Genetics,   Cell Biology,   Bacteriology  |